April 2, 2025 The Best Source of News, Culture, Lifestyle for Culver City, Mar Vista, Del Rey, Palms and West Los Angeles

Scientific Update: Study Unmasks the Genetic Complexity of Cancer Cells in the Same Tumor

A new study led by Cedars-Sinai investigators dramatically illustrates the complexity of cancer by identifying more than 2,000 genetic mutations in tissue samples of esophageal tumors. The findings reveal that even different areas of individual tumors have various genetic patterns.

The study results, published in the journal Nature Genetics, help explain why it is so difficult to battle cancer by targeting a specific genetic defect. A surgeon who performs a single biopsy on a patient’s tumor can decode only part of the tumor and its genetic variations. Additionally, cancer cells constantly change their makeup.

“A tumor is not a single disease,” said Dechen Lin, PhD, assistant professor and research scientist in the Division of Hematology and Oncology in the Cedars-Sinai Department of Medicine. ”It’s many diseases within the same person and over time. There are millions of cells in a tumor, and a significant proportion of them are different from each other.” Lin was the project coordinator for the multicenter study.

The cancer that the team studied, esophageal squamous cell carcinoma, is especially difficult to treat. The disease attacks the esophagus, the hollow tube that connects the throat to the stomach. The five-year survival rate for patients with esophageal cancer is about 20 percent, according to the American Cancer Society.

To create their catalog of mutations, the study’s investigators called on high-powered computers to compile genetic data on 51 tumor samples taken from 13 patients. Through complex algorithms, they analyzed both the genes and the processes, known as epigenetics, that turned the genes’ activities on and off within the cancer cells.

Using these techniques, the investigators identified 2,178 genetic variations in the sampled tumors. Dozens of the variations involved genes known to be associated with enabling the development of cancer. The most striking finding was that many important mutations were detected only in some areas of a tumor, highlighting the complexity of the cancer cells. This finding also demonstrated the potential for inaccurate interpretation of a cancer’s genetic makeup using the single-biopsy method, which is the standard approach in the clinic.

Besides cataloging these genetic variations, the study’s investigators reconstructed a “biography” of the tumors, showing when some of these variations first appeared in the life cycle of the disease.

“This study is on the leading edge of looking within a tumor for heterogeneity, or variations, across patients and within the same patient. It also is one of the very first studies to look at epigenetic changes from different areas within a single tumor in a global way,” said Benjamin Berman, PhD, the study’s co-senior author, an associate professor of Biomedical Sciences and co-director of the Cedars-Sinai Center for Bioinformatics and Functional Genomics.

To meet the challenge of integrating this diverse data, Huy Dinh, PhD, a project scientist in Berman’s laboratory and one of the study’s co-lead authors, developed innovative computational methods.

Looking ahead, the investigators plan to apply their analytic techniques to other cancers and explore the significance of the genetic and epigenetic changes that they have so far identified. They view their work as fundamental to developing effective, individualized therapies to combat the drug resistance that many cancer patients face during the course of their disease.

“Evidence suggests that tumor heterogeneity is one of the major causes of drug resistance and treatment failure in cancer,” said H. Phillip Koeffler, MD, professor of Medicine and the Mark Goodson Chair in Oncology Research at Cedars-Sinai. “In light of this situation, deciphering the genomic diversity and evolution of tumors can provide a basis for identifying new targets and designing personalized medicine strategies.” Koeffler was the other co-senior author of the study.

Real female scientists researching

Related Posts

(Video) Spending an Afternoon at Pacific Park on the Santa Monica Pier

April 1, 2025

April 1, 2025

Go To Pacpark.com For Tickets and More Information. Go To https://t.co/fDDgcY6b3e For Tickets and More Information.#amusementpark #rides #rollercoaster #summer #spring...

Matū Kai to Debut in Brentwood With Grass Fed Wagyu and Global Flair This Week

April 1, 2025

April 1, 2025

Farm-To-Fork Beef, Wood-Fired Flavors, and Sustainability Meet on San Vicente The team behind Beverly Hills’ acclaimed steakhouse Matū has expanded...

Mid-City Freeway Death Under Investigation After Caltrans Workers Find Blanket-Covered Body

April 1, 2025

April 1, 2025

Woman Discovered on 10 Freeway Shoulder Identified; CHP Launches Probe Caltrans workers discovered a woman’s dead body around 9:00 a.m....

Community Support Saves Beloved West Hollywood Café from Closure

March 31, 2025

March 31, 2025

Packed Tables and Emotional Messages Helped Keep the Doors Open Le Petit Four, the popular Sunset Boulevard café known for...

Egg Beaters Recalled Over Possible Chemical Contamination

March 31, 2025

March 31, 2025

Massive Liquid Egg Recall Includes California Shipments Cargill Kitchen Solutions is recalling approximately 212,268 pounds of liquid egg products after...

Los Angeles County’s Measure A Raises Sales Tax On April 1, And It’s No Joke

March 31, 2025

March 31, 2025

Santa Monica, West Hollywood, Culver City, and Malibu Will See Higher Increases Starting April 1, Los Angeles County residents will...

Robbery Boast on Instagram Helps Send Beverly Hills Heist Suspect to Prison

March 31, 2025

March 31, 2025

Flashy Post, Federal Time: Smash-and-Grab Mastermind Sentenced Ladell Tharpe, 39, received an 84-month sentence from U.S. District Judge George H....

Culver City Rolls Out Hi-Lo Siren to Warn Residents During Emergencies

March 31, 2025

March 31, 2025

Hi-Lo Warning System Activated: Culver City Adds New Evacuation Tool In an effort to strengthen emergency preparedness and public safety,...

Union Workers at UCLA to Strike April 1 Over Staffing Shortages, Labor Disputes

March 31, 2025

March 31, 2025

Healthcare and Research Staff at UC to Strike, Alleging Unfair Labor Practices More than 20,000 healthcare, research, and technical professionals...

School of Rock Students Shine in Winter Performance Despite Widespread Fires

March 31, 2025

March 31, 2025

Summer Camp Registration Opens Now By Susan Payne Wildfire devastation wreaked havoc in areas of Los Angeles this January with...

Full House Creator’s Cielo Drive Estate Returns With Massive Price Drop

March 30, 2025

March 30, 2025

Franklin’s Mansion, Once the Site of the Manson Tragedy, Back on Market Full House creator Jeff Franklin is returning to...

Santa Monica, Beverly Hills See Real Estate Shifts After L.A. Wildfires

March 30, 2025

March 30, 2025

Beverly Hills and Brentwood Listings Triple in Wake of January Fires Home sales and listings have shifted dramatically across Westside...

Deputies Open Fire on Suspect in West Hollywood, Triggering Street Closures

March 30, 2025

March 30, 2025

Suspect Shot by LASD in West Hollywood Domestic Violence Response Authorities are investigating a shooting that occurred Saturday evening in...

West Hollywood Resident Returns, Vandalizes Property, 30 Minutes After Eviction

March 30, 2025

March 30, 2025

“Neighbor From Hell” Tried to Re-Enter His Apartment and Damaged Property Valentino Lopez, a 41 year old, male Hispanic, was...

New Deadline, More Access: LA County Debris Program Expands Scope, Extends Signup

March 30, 2025

March 30, 2025

Officials Broaden Scope to Help More Residents, Encourage Early Submission Los Angeles County officials have announced that FEMA has agreed...