March 28, 2024 The Best Source of News, Culture, Lifestyle for Culver City, Mar Vista, Del Rey, Palms and West Los Angeles

UCLA scientists release immune system-related gene study

UCLA scientists have shown that two genes not previously known to be involved with the immune system play a crucial role in
how progenitor stem cells are activated to fight infection, according to a study released Wednesday.

The discovery lays the groundwork for a better understanding of the role progenitor cells can play in immune system response and could lead to the development of more effective therapies for a wide range of diseases.

Results of the two-year study led by Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research member Dr. Julian Martinez-Agosto was published online today ahead of print in the journal Current Biology.

Progenitor cells are the link between stem cells and fully differentiated cells of the blood system, tissues and organs. This maturation process, known as differentiation, is determined in part by the original environment that the progenitor cell came from, called the niche.

Many of these progenitors are maintained in a quiescent state or “standby mode” and are ready to differentiate in response to immune challenges, such as stress, infection or disease.

Dr. Gabriel Ferguson, a postdoctoral fellow in Martinez-Agosto’s lab and first author of the study, built upon the lab’s previous research that utilized the blood system of the fruit fly species Drosophila, showing that a specific set of signals must be received by progenitor cells to activate their differentiation into cells that can work to fight infection after injury.

Ferguson focused on two genes previously identified in stem cells but not in the blood system, named Yorkie and Scalloped, and discovered that they are required in a newly characterized cell type called a lineage specifying cell. These cells then essentially work as a switch, sending the required signal to progenitor cells.

The researchers further discovered that when the progenitor cells did not receive the required signal, the fly would not make the mature cells required to fight infection. This indicates that the ability of the blood system to fight outside infection and other pathogens is directly related to the signals sent by this new cell type.

“The beauty of this study is that we now have a system in which we can investigate how a signaling cell uses these two genes Yorkie and Scalloped, which have never before been shown in blood, to direct specific cells to be made,” said Martinez-Agosto, an associate professor of human genetics. “It can help us to eventually answer the question of how our body knows how to make specific cell types that can fight infection.”

Martinez-Agosto and Ferguson and colleagues next hope that future studies will examine these genes beyond Drosophila and extend to mammalian models, and that the system will be used by the research community to study the role of the genes Yorkie and Scalloped in different niche environments.

“At a biochemical level, there is a lot of commonality between the molecular machinery in Drosophila and that in mice and humans,” Ferguson said. “This study can further our shared understanding of how the microenvironment can regulate the differentiation and fate of a progenitor or stem cell.”

Said Martinez-Agosto: “Looking at the functionality of these genes and their effect on the immune response has great potential for accelerating the development of new targeted therapies.”

Related Posts

Cantonese Dim Sum Master Chef Tony Opens Hollywood Dim Sum at TCL Chinese Theatre

March 27, 2024

March 27, 2024

Experience Exquisite Dim Sum Creations in the Heart of Hollywood 97 years after its founding, the TCL Chinese Theatre will...

Fleurs et Sel Bakery Opens Storefront in West Adams, Welcomes Customers Three Days a Week

March 27, 2024

March 27, 2024

Indulge in Freshly Baked Cookies at the New West Adams Location Fleurs et Sel Bakery, known for its delectable cookies...

Easter Specials Guide: Brunch Spots, Desserts, and More in West Los Angeles

March 27, 2024

March 27, 2024

Discover the Best Easter Eats and Treats in LA for Your Holiday Celebration Easter is almost here, so here are...

(Video) Director Adam Wingard Talks About His Influences While Making GODZILLA X KONG: THE NEW EMPIRE

March 27, 2024

March 27, 2024

Director Adam Wingard Talks About His Influences While Making GODZILLA X KONG: THE NEW EMPIRE at the Beyond Fest Screening...

Attorney for Sean “Diddy” Combs Denounces Investigation as “Witch Hunt”

March 26, 2024

March 26, 2024

Legal Representative Criticizes Probe Amid Federal Sex Trafficking Inquiry An attorney representing Sean “Diddy” Combs criticized the investigation into the...

Culver City Police Department to Conduct High Visibility Traffic Enforcement Operation

March 26, 2024

March 26, 2024

Operation Targets Hazardous Traffic Violations on the West End The Culver City Police Department announced plans to conduct a high...

Historic Union Contract Ratified by Thousands of Hotel Workers At 34 Hotels

March 26, 2024

March 26, 2024

UNITE HERE Local 11 Negotiates Agreement Ensuring Wage Increases  Hotel workers, who spearheaded the largest hotel strike in modern U.S....

Human Rights Campaign’s Los Angeles Dinner Celebrates LGBTQ+ Advocacy and Unity

March 25, 2024

March 25, 2024

Notable Figures Gathered to Champion LGBTQ+ Rights and Combat Discrimination By Aneesha Pappy  The Human Rights Campaign (HRC), the nation’s...

California Bars and Nightclubs Must Offer Drug Testing Devices Starting July 1

March 25, 2024

March 25, 2024

New Law Mandates License Holders to Provide Drug Testing Kits to Patrons Beginning July 1, establishments with Type 48 licenses...

Opinion: West Los Angeles Needs to Care about Veteran Homelessness

March 25, 2024

March 25, 2024

By Kelly Kravchuk  Veteran homelessness is a public health concern that impacts my West Los Angeles community. As a USC...

Culver City City Council Recap: Bruce Lee Alley, Historical Discrimination Study, Women’s History Month

March 25, 2024

March 25, 2024

Council Deliberates on Racial Equity, Infrastructure Upgrades, and Fire Department Strategic Plan The Culver City Council convened its latest session...

Federal Agents Raid Property Linked to Music Mogul Sean “Diddy” Combs In Holmby Hills

March 25, 2024

March 25, 2024

Authorities Conduct Searches in Los Angeles as Part of Ongoing Sex Trafficking Probe Federal agents from the Department of Homeland...

Biden Signs Government Funding Bill with Ban on Pride Flags at Embassies

March 25, 2024

March 25, 2024

White House Vows Repeal Amid Controversy Over LGBTQ Provision President Biden signed a huge government funding package on Saturday, which...

Staples Store in Westchester Could Become a Senior Housing Complex

March 24, 2024

March 24, 2024

Redevelopment Plans Unveiled for Property Near LAX The current site of a Staples retail store near Los Angeles International Airport...

City of Los Angeles Pays Nearly Half a Billion in Liability Claims Over Four Years

March 24, 2024

March 24, 2024

LA Controller’s Report Reveals Significant Payouts from General Fund LA City Controller Kenneth Mejia has continued to audit the City...